A Positive Feedback at the Cellular Level Promotes 1 Robustness and Modulation at the Circuit Level 2

Julie Dethier*, Guillaume Drion*, Alessio Franci, Rodolphe Sepulchre° 3 Department of Electrical Engineering and Computer Science, University of Liège, 4 Liège B-4000, Belgium, Department of Mechanical and Aerospace Engineering, 5 Princeton University, Princeton, NJ 08544, USA, Laboratory of Pharmacology and 6 GIGA Neurosciences, University of Liège, Liège B-4000, Belgium, Volen Center for 7 Complex Systems, Brandeis University, Waltham, MA 02454, USA, Department of 8 Engineering, University of Cambridge, Cambridge CB2 1PZ, UK. 9 *These authors contributed equally to this work 10 °Correspondence should be addressed to Rodolphe Sepulchre 11 ([email protected]) 12 13 Abbreviated title: A Positive Cellular Feedback at the Circuit Level 14 Conflict of interest: The authors declare no competing financial interests. 15 Author contributions: JD, GD and RS designed research. JD and GD performed 16 research. JD, GD, AF and RS analyzed the data: JD, GD, AF and RS wrote the paper. 17 Articles in PresS. J Neurophysiol (August 26, 2015). doi:10.1152/jn.00471.2015